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Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and interacts with the class III PI3-kinase signalling complex to positively control the formation of autophagic vacuoles 48,49

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Conversely, the C@PA MN (+) group showed impaired wound healing due to aggravated oxidative stress caused by RS production, as shown in Fig

This work was partially financially supported by the University of Padova (Grants 60A04-0443, 60A04-3189 and 60A04-4015/15)

In addition to its participation in the WWC, ascorbate is also required for the regeneration of lipid-soluble antioxidants, particularly tocopherols and tocotrienols (vitamin E), which protect the polyunsaturated fatty acids in the thylakoid membranes from oxidation to chromanoxyl radicals by singlet oxygen

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