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35 There is also compelling evidence that vitamin B 12 deficiency occurs frequently during pregnancy, 2 6 7 and case studies have demonstrated harmful effects of severe vitamin B 12 deficiency on the developing infant brain

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Individuals with certain genetic predispositionssuch as variants in methionine synthase (MTHFR) and cobalamin metabolism pathwaysmay respond more distinctly to B vitamin protocols

Copper transport into the nucleus is facilitated by CCS and subsequently mediated by the copper-binding protein (CuBP) (49)