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When B12 levels become problematic: High-dose supplementation (particularly doses exceeding 1,000 micrograms daily) Frequent B12 injections without medical supervision Underlying conditions affecting B12 metabolism Concurrent use of multiple B12-containing supplements The NHS does not set an upper safe limit for vitamin B12 because harmful effects from excessive intake have not been definitively established

the damage is done

However, an air bubble in your syringe means the liquid volume is less than what the markings indicate

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In the vegetarian diet, there are few sources of Cobalamin and its shortage can have serious implications