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CTI may serve as a potential risk marker reflecting integrated metabolicinflammatory burden, which could be useful for population-level risk characterisation rather than for direct clinical decision-making

Supplementation experiments The following supplements were obtained from HiMedia BioSciences: ferric chloride (#TC583), N-acetylcysteine (NAC) (#RM3142), and 2,2-bipyridyl (#GRM791)

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Weeks 1-4: 0.25 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Weeks 5-8: 0.5 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Weeks 9-12: 1.0 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Weeks 13-16: 1.7 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Week 17 and beyond: 2.4 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Some providers modify this schedule based on individual tolerance