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Lets break down the likely culprits

Numbness and tingling in the hands and feet, depression, confusion, or poor memory can also occur
Your research data becomes unreliable

Pappas, C

Five unique GSTP1 -specific shRNA plasmids (clones TRCN0000083 773 , TRCN0000083 774 , TRCN0000083 775 , TRCN0000083 776 and TRCN0000083 777 ) and a negative control plasmid (empty vector control, SHC001) were purchased as glycerol stocks and plasmid DNA extracted using plasmid DNA maxi prep kits (Qiagen, Manchester, UK) according to the manufacturers instructions
Crosstalk between calcium and redox signaling: from molecular mechanisms to health implications