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One article proposed that excessive serotonin levels could explain classic symptoms of ME/CFS (433), as it would promote the release of excess CRH, and therefore cause chronic reactivation of the HPA axis (434)

Lisdexamfetamine: a prodrug for the treatment of attention-deficit/hyperactivity disorder

[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Cheng J.B., Levine M.A., Bell N.H., Mangelsdorf D.J., Russell D.W

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The liver is the largest organ providing immune and metabolic functions, and its ectopic lipid accumulation has been widely recognized as one of the factors potentially influencing PCOS metabolic syndrome, despite ongoing debates about the causal relationship between hepatic fat deposition and hepatic insulin resistance in recent years, the correlation between the two is undeniable (Rocha et al., 2017)