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For a drug administered orally, bioavailability may be less than 100% for two main reasonsincomplete extent of absorption across the gut wall and first-pass elimination by the liver (see below)
doi: 10.1038/bjp.2008.99
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In HK-2 cells, iopromide also activated IRE1-, eIF2-, and JNK-related stress pathways, leading to CHOP upregulation, Bax/Bcl-2 imbalance, and caspase-3 cleavage
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