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AGEs react with amino acid residues in proteins, forming irreversible modifications that negatively affect sperm, including reduced sperm count, decreased motility, increased morphological abnormalities, residual histones, fish sperm protein deficiency, sperm DNA fragmentation, decreased antioxidant capacity in the testes, and elevated levels of receptor for advanced glycation end products (RAGE) and carboxymethyl lysine (CML) proteins [160]

To define the relationship between oxytosis and ferroptosis, a clear set of markers, assays, and reagents for inducing and inhibiting oxytosis and ferroptosis are needed, to enable a systematic side-by-side comparison of similarities and differences between these modes of cell death

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