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Statistics Sample sizes were determined using G power 3.9.1.7 software and statistical analysis was performed using Graphpad Prism 9.4.0

Vitamin C, Vitamin E, and Kojic Acid Protect the Skin From Sun Damage and Free Radicals Exposure to harmful UV rays and free radicals may cause premature skin aging, dark spots, or saggy skin , among others

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For example, enhancing oxidative phosphorylation in microglia might promote a more quiescent, neuroprotective state, while targeted inhibition of glycolysis could reduce harmful inflammation (Barros et al., 2009

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By bridging traditional practices with modern scientific understanding, this review underlines the growing relevance of shiitake not only as a functional food and therapeutic resource but also as a component of sustainable food systems and bio-based waste management strategies