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From the analysis of structure-activity relationship studies, it can be concluded that the introduction of a 4-phenyl group contributes to the binding to cereblon

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[DOI] [PubMed] [Google Scholar] 7.Larsen T.O., Svendsen A., Smedsgaard J

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It is estimated that it affects up to 1 in 300 individuals The variants can happen in one of four mismatch repair (MMR) genes, called MLH1, MSH2, MSH6, and PMS2