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The primary preclinical evidence comes from mouse studies showing reduced body weight and adipose mass in diet-induced obese mice (2018), improved grip strength in aged mice (2024), and beneficial microbiome changes when combined with caloric restriction (2022)

A wider, more stable shoe is more helpful compression around the forefoot often makes it worse

Maximum concentrations are measured 2-4 hrs after the plasmatic peak

Before beginning therapy, always let your healthcare professional know about any allergies or underlying medical issues

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However, it's best to consult your doctor before using this medicine during pregnancy