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In clinical trials, Ipamorelin was well tolerated, with no significant effects on prolactin or cortisol secretion compared to other GHRPs. van den Berghe et al., The Journal of Clinical Endocrinology & Metabolism Rare or Potential Concerns Injection site irritation (especially with poor reconstitution technique) Overstimulation of GH axis with excessive dosing or stacking GH-related side effects at high doses (e.g., mild carpal tunnel, joint tightness) These are more likely in unsupervised high-dose or long-term protocols , especially when paired with additional GH-enhancing compounds

(in)GSH is inexpensive ($50/month), can be self-administered, and may be a novel method of directly reaching target tissues of the respiratory tract and CNS

A randomized, double-blind, placebo-controlled, stratified trial of riluzole 100 mg daily, given as 50 mg twice daily, demonstrated a statistically significant survival benefit at 12 and 21 months, with median survival increasing by 83 days [113], with more robust survival effect seen in patients with bulbar onset disease