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Some of these symptoms can include anemia, a build-up of too much acid in the body and frequent infections

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Some class II GRXs appear to catalyze deglutathionylation through a monothiol mechanism, the intermediate glutathionylated GRX likely being resolved by formation of an intramolecular disulfide between the active site Cys and a partially conserved C-terminal Cys

What is known is, that disruptions in mitochondrial function and mtDNA integrity can contribute to the development of neurological disorders [109], and fumarate has been shown to play a role in various cellular processes related to neuronal function, such as oxidative stress and inflammation [110, 111]

Modulation of extracellular glutamate concentration in rat brain slices by cystine-glutamate exchange

Mol Pharmacol 1997