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Curcumin plays a pivotal role in reducing angiogenesis and microvessel density within adipose tissue by downregulating the expression of Vascular Endothelial Growth Factor (VEGF) and VEGF Receptor 2 (VEGFR-2)

At the immune and inflammatory interface, polyamines suppress NF-B p65 translocation and attenuate PI3KAKT and MAPK activation, reducing inducible nitric oxide synthase (iNOS) and COX-2 expression and the subsequent production of NO, prostaglandin E 2 (PGE 2 ), and cytokines such as TNF-, IL-1, and IL-6 [229]

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Ongoing clinical trials are exploring other applications of CD38 antibody containing IgA nephropathy (NCT05065970) and even metastatic renal cell carcinoma (NCT03473730).The study( NCT05704400 )is researching the effectiveness of the combination therapy of CD20 monoclonal antibody and daratumumab monoclonal antibody in the treatment of pediatric multidrug-resistant nephrotic syndrome ( Table 2 )

CI is a large 45-subunit L-shaped complex in the mitochondrial inner membrane 15

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