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doi: 10.1007/s00204-023-03562-9 12 JuchnowiczDDzikowskiMRogJWaszkiewiczNZalewskaAMaciejczykMet al
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In addition, folate is necessary in the synthesis of dTMP from dUMP (66)
Compared with stable states such as substrates, intermediates, or products, the enzyme has a significantly greater affinity for unstable transition states, thereby reducing the energy barrier during the reaction
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