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Description
Expression microarray and quantitative PCR analysis identified circFRMD4A as a p53-regulated circular RNA that is induced by DNA damage stress (5-FU/cisplatin) and MDM2 inhibitors (nutlin-3 and APG-115) in wild-type p53 (wtp53)-harboring cancer cells
The pivotal roles of the PINK1-Parkin axis in maintaining mitochondrial integrity have been extensively documented in various experimental models (58)

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Full therapeutic doses are a separate and more promising story, now in trials for depression and, as covered above, in an early test in Parkinsons

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[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Bobeck E.A