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Biologic therapies, such as anti-TNF- monoclonal antibody and JAK inhibitor, primarily consist of small molecules targeting specific pathways, effectively inducing and maintaining remission

Maintaining or adding NADPH in therapeutic dosages might help to overcome high levels of ROS, keep a stable level of GSH in the brain, and finally result in neuroprotection

128 Although the antioxidant effect of UA might have therapeutic benefits, high plasma concentrations of UA have been associated with obesity, insulin resistance, and hyperuricemia

However, the findings by both Zheng et al

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