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In addition, Serine and arginine rich splicing factor 9 (SFRS9) can upregulate the expression of GPX4 by binding to GPX4 mRNA, which promote the growth of CRC, while SFRS9 knockdown significantly inhibited tumor growth in nude mice (Wang R
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Once secreted from the pineal gland, melatonin is bound to albumin in the blood, metabolised to 6-hydroxymelatonin by cytochrome P-450 isoforms and conjugated in the liver to produce the principal urinary metabolite, 6-sulfatoxy-melatonin, which is eliminated through the kidney [3]
