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Cortical neurons from G2019S- LRRK2 mice are more vulnerable to stress injury, and exposure to subtoxic doses of MPTP can cause severe motor dysfunction, selective loss of DA neurons, and increased astrocyte activation [101]

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Proc Natl Acad Sci U S A 105:2085820863

Nicotinic receptors, specifically, are considered potential therapeutic targets for treating depression

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