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Sphinganine interacts with the transcription factor c-Fos, inducing the transcription of target genes, such as Pdcd1 which promotes the differentiation of regulatory T cells and thereby suppresses anti-tumor immunity 136

(2016) described that, besides activating GABA B receptors in astrocytes, GABA release by interneurons also activates GABA A receptors in presynaptic neurons, which inhibited synaptic activity

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