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The ethosomal gel had good skin deposition, which allowed curcumin to stay in the skins deeper layers for a longer duration of time, aiding in the full destruction of melanoma cells without inflicting significant discomfort to the skin ( Also, with the use of Carbopol-934 and sodium CMC as the polymer, camptothecin extracted from Nothapodytes nimmoniana may be administered by transdermal route in the form of a herbal gel formulation

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