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This is exactly what you would expect from a drug whose cardiac effects are driven by receptor activation, more drug means more receptor binding means more cAMP means faster heart rate

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CrossRef PD-L1 Expression and Overall Survival in Asian and Western Patients with Gastric Cancer Sun Young Rha, Geoffrey Y Ku, Hyo Song Kim, Hyun Cheol Chung, Fatemeh Ghazanfari Amlashi, Dipen Maheshbhai Maru, Carly A Fein, Laura H Tang, Wei Zhou, Ting Wu, Senaka A Peter, David P Kelsen, Jaffer A Ajani Future Oncology.2022

doi: 10.1186/s11658-021-00263-y

The debated issues are mainly related to dose, specificity, potency, feasibility and short-or long-term side effects in humans

These findings highlight the fact that not all PAMs of a given receptor behave similarly in vivo , which must be taken into account when designing studies evaluating their therapeutic potential