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VIP also regulates the activity of immune cells, such as T cells and macrophages, promoting a more controlled immune response

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Significant weight loss particularly reduction of visceral fat is associated with improvements in testosterone levels in men with obesity-related hypogonadism, as visceral fat drives conversion of testosterone to oestrogen

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And it is secreted out of the cells in the precursor form (pro-HGF) and also activated by the proteolytic cleavage at the Arg-Val site (Naka et al., 1992