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To date, there are no studies showing the concentration of helminth cystatins that come in contact with DCs during in vivo infection, but the concentrations used in this study were titrated in the laboratory and found 1 M Al-CPI as the optimal to induce cytokine response in moDC

this, in turn, leads to accentuated elevations in blood concentrations of tHcy and MMA, and exacerbation of neurological sequelae due to vitamin B-12 deficiency in the brain and peripheral nervous system To test these and other predictions, in addition to human studies, it will be important to develop better animal models with closer similarity to the physiologic and clinical features of vitamin B-12 deficiency than rodent models currently provide

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Pancreatitis was reported as a rare serious adverse event in clinical trials

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