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Short-term dietary SAAR in humans elicits decreases in body weight, body mass index (BMI), and liver fat (1214)

Industrial purification of glycine betaine is done by extraction with water (384) and subsequent ion exchange chromatography (384,385) , which can be done in simulated moving bed fashion (386)

Experimental model and subject details Patients Patients were aged between 3 and 16 years old with the exception of P6 being 36 years old and were included based on molecular diagnosis of biallelic loss of function mutations in SAMHD1 , RNASEH2B or ADAR1 genes for AGS or dominant-negative mutation in COPA gene for patients with COPA disease

doi: 10.1186/s13229-020-0313-1

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