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doi:10.1093/ajcn/nqac055 Ramli NNS, Alkhaldy AA, Mhd Jalil AM

In a clinical trial of valproate as monotherapy in patients with epilepsy, 34/126 patients (27%) receiving approximately 50 mg/kg/day on average, had at least one value of platelets 75 x 109/L

While our body can make CoQ10, some people have genetic variations that do not produce sufficient levels, and levels can also decline with aging, medications such as statin drug use to lower cholesterol, and other factors

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Psychiatry 13, 930714

Genetic testing strategys A recommended screening strategy (Figure 1) is to firstly screen exons 3 and 4 for mutations using PCR-based techniques such as denaturing HPLC and sequencing, as the majority of mutations are seen in this region If no mutation is identified further screening of exons 1 and 2 is recommended