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This effect was abrogated by inhibiting NOSs or guanylate cyclase, implicating NO/cGMP signaling pathway in this process ( Figure 1 )

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Possible side effects of IGF-1 LR3 administration can include [1, 14, 15]: Hyperandrogenism Muscle and joint pain Nausea Headache Impaired glucose metabolism and hypoglycemia Fatigue Changes in sexual function Soft tissue swelling Researchers should thoroughly check glucose, cholesterol, and bone density levels before administering IGF-1 LR3 to test subjects

Irisin attenuates type 1 diabetic cardiomyopathy by anti-ferroptosis via SIRT1-mediated deacetylation of p53

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