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[3] [4] Ergothioneine was discovered by Charles Tanret in 1909 and named after the ergot fungus from which it was first purified, [5] with its structure being determined in 1911

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Specifically, lactate mitigates inflammation by inhibiting TLR4-mediated signaling via GPR81, thereby facilitating the polarization of M2 macrophages and diminishing LPS-induced NF-B activation (154158) Additionally, lactate influences immune cell migration and cytokine production through its export via the monocarboxylate transporter MCT4

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