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In contrast to acyl-CoAs, which remain sequestered in mitochondria, ACs can be transported out of mitochondria and out of the cell to the blood-stream and thereby directly reflect the intracellular pool of corresponding acyl-CoAs( Peroxisome proliferator-activated receptor alpha (PPAR) is a transcription factor that regulates transcription by binding to the PPAR response elements of several genes, including genes related to mitochondrial and peroxisomal -FAO ( In this study, we propose to investigate the possible mechanism of VPA-induced disorder of ACs profiles, relative gene expression, including ACs transport and -FAO enzyme was tested at the cellular and animal levels to explore the candidate biomarkers for VPA-induced abnormal liver function

doi: 10.1017/S0012162205000332

185(2): 2748 Fritz IB, Schulz SK, Srere PA

It plays a specific and well-defined metabolic role: it transports long-chain fatty acids across the mitochondrial membrane so they can be oxidised for energy

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