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For vegans, it is important to note that most commercially available creatine supplements, including creatine monohydrate, are synthesized chemically and do not come from animal sources

doi: 10.1016/j.ijbiomac.2021.10.026 320 XuPWuZPengYGaoJZhengFTanJet al

Shoja MM, Tubbs RS, Ghabili K, Loukas M, Oakes WJ, Cohen-Gadol AA: Johan Georg Raeder (1889-1959) and paratrigeminal sympathetic paresis

2022 ed.)

In fact, vegetarians and vegans have been shown to have significantly reduced TMAO levels compared to meat-eaters

The definition of very low certainly is that we have very little confidence in the effect estimate (the true effect is likely to be substantially different from the estimate of effect)