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This study is just the tip of the iceberg
The level of DHFR activity in the human liver is relatively low such that high levels of folic acid intake (such as by megadosing vitamins) can lead to pathological consequences
Link to non-clinical (e.g
On the other hand, decreased GSH level was found to enhance oxaliplatin sensitivity (Mohn et al., 2010)
PDB buffer served as mock in these infection assays
