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Although endotheliosis is a consistent feature of all thrombotic microangiopathies, the degree and prominence of endothelial swelling observed in patients on VEGF inhibitors is most similar to the TMA of preeclampsia
In addition, mitochondrial dysfunction in stromal cells is the key causal factor triggering fibrosis-induced ovarian decline, and metformins reversal of ovarian fibrosis converges on related mitochondrial metabolic pathways that are upstream of oxidative stress and inflammation (Umehara et al., 2022)
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