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Subsequently, lipid peroxidation promoted the activation of IB kinase- (IKK)/NF-B, which further mediated chronic inflammation and impaired insulin signaling by inhibiting insulin-stimulated phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB) activities (53)

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Once opened, discard any unused solution 28 days after first puncture or on the beyond-use date provided by the pharmacy, whichever comes first

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