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Abstract Schizophrenia is a serious psychiatric disorder of multifactorial triggers, with a lifetime prevalence of about 1% in all countries of the world, with a slightly higher prevalence in males than in females, and with a peak incidence between the ages of 15-35 years old, and a poor prognosis for most of the patients, which imposes a heavy burden on the society and the family

Animal studies indicated that early NAC treatment protects by scavenging NAPQI and by preventing protein adduct formation [66]

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A total of 1,421 metabolites were identified across the three groups, including 812 in positive ion mode and 609 in negative ion mode

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