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Description
RANKL: activator of nuclear factor kappa B

NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler

Proc Natl Acad Sci USA 98 : 1207212077
Sun Y, Yu M, Liang S, Zhang Y, Li C, Mou T, et al

Kleba, B., Clark, T
Screening and development of small molecules to inhibit the binding sites of the two proteins are topical not only in the context of FRDA but also in other neurodegenerative and inflammatory diseases (reviewed in Combating repressive chromatin marks and epigenetic FXN silencing, histone deacetylase inhibitor 109/RG2833 treatment in a neuronal cell model increases both FXN mRNA and protein levels concomitant with increased H3K9 acetylation in patient clinical trials (Soragni et al., 2014)