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Even minor fluctuations that occur repeatedly during feeding/fasting cycles, integrated over time, can cause downstream biochemical changes (e.g., 1-deoxysphingolipids) to accumulate over time and ultimately reach a threshold at which they cause disease

doi: 10.1007/s00128-019-02774-z 96 de SouzaJSKizysMMda ConceicaoRRGlebockiGRomanoRMOrtiga-CarvalhoTMet al

These neurobiological improvements align closely with enhanced social and cognitive performance, underscoring neuroinflammation as a promising therapeutic target [93, 96, 97]

This state will fully last for another 5 or 6 hours

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