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If you havent seen improvement by the time you reach 10 mg (roughly two to three months in, depending on titration speed), its time to evaluate other factors: diet, exercise, sleep, medical conditions, and interfering medications

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Gonzales MM, Garbarino VR, Kautz TF, Palavicini JP, Lopez-Cruzan M, Dehkordi SK, Mathews JJ, Zare H, Xu P, Zhang B, Franklin C, Habes M, Craft S, Petersen RC, Tchkonia T, Kirkland JL, Salardini A, Seshadri S, Musi N, Orr ME

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Did taking an eggshell membrane supplement (a source of collagen) improve symptoms and joint space in people with knee osteoarthritis

This is because it takes a really long time, and it may be difficult to portion that type of time commitment before you truly know you enjoy the effects