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In this model system, when we performed cytotoxicity assays in the presence or absence of 10 M valspodar, a P-gp inhibitor, we observed that P-gp overexpression conferred resistance to imidazole ketone erastin, piperazine erastin, and FIN56, and that valspodar reversed the resistance

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Randomized trials have demonstrated that exogenous melatonin can be of benefit in a number of sleep disease states including delayed sleep phase syndrome, non-24-hour sleep-wake syndrome, jet lag, and insomnia

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