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This knowledge gap doesnt mean the connections dont existonly that they deserve more rigorous investigation

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Importantly, peptide analogs with stapling moieties present at the hydrophobic interface (1914, 1919, 1921, 2015, 2017) had limited improvement or even loss of activity compared to LD2, suggesting that substitution of these interfacial residues disrupted key hydrophobic interactions (Table 1)

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I recommend testing every 36 months, especially if you follow a plant-based diet, as dietary intake may be limited