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[DOI] [PubMed] [Google Scholar] 51.Burde RM, Schainker B, Kayes J

Aberrant redox homeostasis and elevated ROS levels in the TME have historically made ROS elimination an attractive therapeutic strategy

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Accumulation of 8-OHdG, induced by hydroxyl radicals, serves as a marker of DNA damage and can be detected in both liver tissue and urine, correlating with disease activity

GPx1 deficiency also enhanced angiotensin II-mediated cardiac hypertrophy, increasing total cardiac mass, left ventricular mass, and left ventricular cardiomyocyte cross-sectional area compared to the changes found in wild type mice