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( A ) Seahorse assay data for untreated, rapamycin-treated (10 nM, 24 hours), and RMC-6272treated (10 nM, 24 hours) HCV29 cells (parental cells), and untreated HCV29RP cells shows an increase in OCR in the RP cells following both oligomycin and carbonyl cyanide p -trifluoromethoxyphenylhydrazone (FCCP) treatment

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[ 14 ] Generally, lipid conjugation enhances the delivery of macromolecules by increasing hydrophobicity and membrane affinity, facilitating cellular uptake and endothelial permeability

2001) and contributes significantly to oxidative stress in the liver