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Early microarray studies provided the first genome-wide snapshots of age-associated changes in gene expression, whereas the adoption of bulk RNA-seq enabled more comprehensive and less assumption-driven discovery, including detection of low-abundance transcripts and isoform-level regulation

Modified or artificial MPs can be used as drug delivery systems for better chemotherapeutic outcomes in MDR cancer cells

This failure is largely due to testing exclusively on cancer cell lines grown in liquid medium, a condition that predicts in vivo efficacy to anticancer drugs worse than cell culture in 3D gels [4, 5] and is far from adequately reflecting the therapeutic responsiveness of cancers within their native microenvironment [2, 3]

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And medicines like alpha-blockers and anticholinergics relax your bladder muscle so you don't have to pee as urgently

Chronic physiological shear stress inhibits tumor necrosis factor-induced proinflammatory responses in rabbit aorta perfused ex vivo