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however, it can also create a reductive microenvironment that paradoxically may aid advanced tumors, reflecting the complex dual role of Nrf2 in cancer

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In primary OPCs, knockdown of BACH1 using siRNA resulted in upregulation of MHCI genes, such as H2Q4 and H2Q7, and MHCII pathway gene Cd74 under the stimulation of IFN, indicating that some immune genes are negatively regulated by BACH1 in OPCs in response to IFNmediated induction

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