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GHK-Cu exerts its effects primarily through gene expression modulation, influencing approximately 31% of the human genome by upregulating genes involved in antioxidant responses, DNA repair, protein metabolism, and cellular growth while downregulating inflammatory mediators, fibrinogen synthesis, and pathological processes including cancer metastasis

This multi-receptor interaction profile differentiates GLP-3R from earlier peptide constructs that primarily targeted single-pathway or dual-pathway receptor activity

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