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GH therapy in children who have previously received craniospinal radiotherapy does prevent further height loss but does so at the expense of further exaggerating the skeletal disproportion seen in these patients

In initial animal studies, that elucidated the role of glucose metabolism in insulin secretion, the rodent GLUT2 transporter was identified as the major sensor and transporter of glucose in pancreatic -cells

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This recognition encouraged preclinical studies aiming to investigate both mechanistic aspects and intervention strategies to characterize and target this biological axis in conditions affecting muscle, brain, the immune system, and metabolic diseases

Li and Sha, 2008