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This includes cellular metabolic balance, including glucose metabolism [5], lipid metabolism [6], and amino acid metabolism

If a person had a deficiency of these vitamins, they were more likely to develop insulin resistance, hyperlipidemia, and obesity which are key pathways involved in the pathophysiology of PCOS [133]

Our mapping of functional metabolic states and the underlying metabolic protein regulome further showed that elevated mTOR:AMPK phosphorylation ratio with upregulation of OXPHOS, glycolytic and fatty acid oxidation metabolism underlies the metabolic hyperactivity of the immunosuppressive phenotype of tolerogenic DC

Ferrari, L., Carugno, M

Figure 1 (B) The manganese peroxidase (1YYD) monomer from Phanerochaete chrysosporium and its heme iron plus Mn 3+ (Sundaramoorthy et al., 2005)