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Supplementary Table 1 The target miRNAs of AQP4

These include peroxiredoxins 47 such as catalase (CAT) 48 , glutathione peroxidases 49,50 , and mitochondrial nicotinamide nucleotide transhydrogenase (NNT) 51 , which act as sinks to remove H 2 O 2 and maintain non-deleterious physiological levels

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These recurring sores often point to underlying issues such as nutritional deficiencies or weakened immunity

Therefore, one possibility to explain increased bleeding in anemic conditions without concomitant hemolysis is that a decreased number of RBCs may decrease NO scavenging and increase NO bioavailability, thereby inhibiting PLT aggregation and leading to bleeding complications (11, 65)

Glutathione protects many thiol groups in molecules such as proteins and enzymes, so that the enzymes maintain their biological activities