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The gastrointestinal tract plays a key role in Mn uptake, mediated by metal transporters, and these transporters can also contribute to Mn excretion via the gastrointestinal tract and the hepatobiliary system (Aydemir et al., 2020

however, no appreciable changes in body weight, blood pressure, fasting blood glucose, or other lipid values were found

438 A variety of copper ionophores have been developed as anticancer agents to promote cuproptosis, with ES and DSF being among the most extensively researched

Its proposed mechanism is to stimulate lipolysis (the breakdown of stored fat) and to inhibit lipogenesis (the formation of new fat), apparently through -adrenergic-related pathways, while unlike full-length GH not raising IGF-1 and not impairing glucose tolerance [1] [5]

Best Practice Res Clin Endocrinol Metabol 28:519631 Medeiros-Neto G, Marui S, Knobel M (2008) An outline concerning the potential use of recombinant human thyrotropin for improving radioiodine therapy of multinodular goiter