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This deficiency restricts tissue uptake, leading to decreased accumulation in the heart and skeletal muscle and potentiates increased renal carnitine loss [21,22] leading to systemic carnitine depletion [23]
18 Cellular hyperglycemia disrupts mitochondrial oxidative phosphorylation, fatty acid metabolism, and key signaling pathways crucial for metabolic stress adaptation, tissue integrity, and immune responses in diabetic complications
Guerreiro G, Faverzani J, Jacques CED, Marchetti DP, Sitta A, de Moura Coelho D et al (2018) Oxidative damage in glutaric aciduria type I patients and the protective effects of l-carnitine treatment
Several species of cholesteryl ester with polyunsaturated fatty acids (CE18:2, CE18:3, CE22:4 and CE24:4) were upregulated in APOE 4/4, while CE 16:0 was downregulated
For this reason, fatigue remains a challenging symptom for clinicians to address
