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In addition, VD administration could activate the endogenous target factor silent mating type information regulation 2 homolog-1 (SIRT1), reducing transcriptional activity, and then inhibit NF-B pathway-mediated neuroinflammation, as well as down-regulating the expression of the downstream signaling molecules TNF- and IL-1 [61]

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Petersburg Institute of Bioregulation and Gerontology, Epithalon was synthesized based on the amino acid composition of epithalamin, a naturally occurring polypeptide complex extracted from the bovine pineal gland